Acne happens!

Don't panic. For most, acne appears as a young teenager and starts to clear up after a few years. But for many, acne can last well into adulthood.2 Although health complications related to acne are rare, it can lead to permanent scarring.3 Early treatment of your acne may help with scarring.4 Acne can negatively affect the quality of your life, but there is good news.5-6 Treatment options are available!

Know your enemy

Before we talk about fighting your zits, let's better understand exactly what causes them in the first place.

So, you probably already know what happens when puberty hits. Your body starts producing hormones like crazy, which stimulates the production of sebum, the stuff that makes your skin oily.3 Sebum is a food source for the bacteria that causes acne called Propionibacterium acnes. We'll call it P. acnes for short.

When excess sebum mixes with loose dead skin cells (we all shed!), it results in a clogged pore that can trap P. acnes.3 The P. acnes begin to feed off of the sebum, and because they thrive in the absence of oxygen, the bacteria begin to multiply quickly.3 That's when your immune system kicks off an inflammatory response, causing the pore to become swollen, red and painful.3 You have a zit!

Fighting zits

Although there is no cure, there are products available to fight acne. First step — see your doctor. Because there are different things going on to cause your acne, he or she may prescribe more than one product to make sure all your bases are covered.

If your acne is severe, your doctor may prescribe ACTICLATE® Tablets. ACTICLATE® Tablets contain doxycycline hyclate, which is the same doxycycline antibiotic sometimes used to treat bacterial infections.7 Scientists think doxycycline works in acne because of its effectiveness against P. acnes bacteria.7 Doxycycline has also been shown to have anti-inflammatory activity, so it may also help with inflammation.8-9

ACTICLATE® Tablets are easy to afford.

ACTICLATE® Tablets are supported by the Aqua SuccessFill™ program.

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Important Safety Information


ACTICLATE® (doxycycline hyclate USP) Tablets are indicated for adjunctive (combination) therapy in severe acne.

Important Safety Information for Patients Regarding ACTICLATE® (doxycycline hyclate USP) Tablets, 150 mg and 75 mg

ACTICLATE® Tablets are an antibiotic in the tetracycline class. ACTICLATE® Tablets should be used only to treat infections caused by bacteria that are killed or inhibited by doxycycline. You should take ACTICLATE® Tablets exactly as your doctor prescribed in order to ensure that it will remain useful as a treatment for this and other appropriate infections.

Who should not take ACTICLATE® Tablets:

You should not take ACTICLATE® Tablets if you have had an allergic or other reaction to doxycycline or another tetracycline antibiotic.

Warnings and Precautions:

  • Taking ACTICLATE® Tablets during pregnancy may cause a permanent discoloration in your baby's teeth.
  • Children under the age of 8 years may develop a permanent change in color (yellow, gray, brown) in their teeth by taking ACTICLATE® Tablets.
  • Diarrhea has been reported with the use of ACTICLATE® Tablets and may range from mild diarrhea to fatal colitis. If you develop watery or bloody stools (with or without stomach cramps and fever), contact your doctor as soon as possible to rule out the possibility of Clostridium difficile-associated diarrhea (CDAD).
  • Taking ACTICLATE® Tablets may increase your sensitivity to sunlight and may cause a more severe sunburn-type reaction. You should avoid and/or limit sun exposure while taking ACTICLATE® Tablets.
  • Increased pressure in the skull has been reported with the use of tetracycline drugs like ACTICLATE® Tablets. Contact your doctor if you experience headaches, blurred vision, double-vision or vision loss. Overweight women of child-bearing age or those who have ever been diagnosed with Intracranial Hypertension (also known as IH or Pseudotumor Cerebri) are at greater risk for developing this side effect.
  • You should drink fluids liberally along with doxycycline to reduce the risk of esophageal irritation and ulceration.

Side Effects:

Some patients taking tetracyclines like ACTICLATE® Tablets have reported side effects including: anorexia (decreased appetite), nausea, vomiting, diarrhea, rash, increased sensitivity to sunlight, hives, and anemia (low red blood cells or hemoglobin). Additional side effects reported with the use of doxycycline hyclate include impaired kidney function, abnormal blood cell counts, swelling, worsening of systemic lupus, and Stevens-Johnson syndrome (a severe inflammatory eruption of the skin and mucous membranes).

Other Medications:

  • Birth control pills may be less effective while taking ACTICLATE® Tablets.
  • Avoid use of tetracyclines while also taking penicillin.
  • Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate, and iron-containing preparations.

Use During Pregnancy and Nursing:

  • ACTICLATE® Tablets are considered a Pregnancy Category D, which means there is evidence of risk to fetus, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
  • Avoid taking ACTICLATE® Tablets while nursing.

This list of side effects, warnings, and precautions is not complete. You can refer to the attached ACTICLATE® Tablets Prescribing Information or your healthcare provider can discuss with you additional considerations prior to taking ACTICLATE® Tablets.

To report SUSPECTED ADVERSE REACTIONS, contact Aqua Pharmaceuticals at 1-866-665-2782, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.